Prayer for Depression: Depression can feel like walking through a never-ending shadow. It can isolate the heart, cloud the mind, and drain every drop of strength. Whether you or someone you love is experiencing this pain, prayer can be a lifeline. In the silence, in the darkness, God is still near. These 40 powerful prayer for depression are meant to speak light into that darkness, hope into the despair, and peace into the anxiety.
We’ve crafted each prayer to be short, simple, and deeply personal—accompanied by Bible verses that remind us of the unchanging truth of God’s love and faithfulness. Even when it’s hard to speak, these prayers are here to help guide your soul back to comfort and calm. When emotions are too heavy and thoughts spiral, prayer gives us something solid to hold on to—God’s Word, God’s promises, and God’s presence.
Let these 40 powerful prayer for depression serve as a daily anchor, reminding you that you are not alone. Each one is a gentle reminder that there is still light, even in the darkest moments. God sees you. God hears you. And He walks with you.
Whether you’re whispering these prayers at night or speaking them through tears during the day, let them be steps toward healing. In the quiet strength of these words, may your spirit be lifted and your heart find rest.
These 40 powerful prayer for depression, and trust that healing is possible, peace is coming, and God is already at work in the deepest places.
Prayer for Depression
1. When It Feels Too Heavy
“Come to me, all you who are weary and burdened, and I will give you rest.” – Matthew 11:28
Dear Lord, I’m tired. Please lift this heaviness from my soul and let me rest in You. Amen.
2. Hope in the Darkness
“The light shines in the darkness, and the darkness has not overcome it.” – John 1:5
Jesus, shine Your light into my mind and heart. Let me know I’m not alone in this darkness. Amen.
3. One Day at a Time
“Therefore do not worry about tomorrow, for tomorrow will worry about itself.” – Matthew 6:34
God, help me take one breath, one moment, one day at a time. That’s all I can do right now. Amen.
4. God of My Emotions
“He heals the brokenhearted and binds up their wounds.” – Psalm 147:3
Lord, my emotions are all over the place. Please meet me here and bring healing. Amen.
5. When I Can’t Feel You
“The Lord is close to the brokenhearted.” – Psalm 34:18
Father, I don’t feel You right now, but I trust You’re still near. Don’t let me go. Amen.
6. Peace Instead of Panic
“You will keep in perfect peace those whose minds are steadfast, because they trust in you.” – Isaiah 26:3
Lord, settle the racing thoughts. Replace my panic with peace. Amen.
7. Strength to Keep Going
“My grace is sufficient for you, for my power is made perfect in weakness.” – 2 Corinthians 12:9
Jesus, I feel weak. Be my strength today and help me not give up. Amen.
8. You Are Still God
“Be still, and know that I am God.” – Psalm 46:10
Even when everything feels broken, You are still God. I trust You. Amen.
9. I Choose to Breathe
“Let everything that has breath praise the Lord.” – Psalm 150:6
Lord, I’m still breathing. Help me use each breath to seek You. Amen.
10. For the Lonely Moments
“Never will I leave you; never will I forsake you.” – Hebrews 13:5
Jesus, when I feel invisible, remind me You see me. Be my comfort today. Amen.
11. Remind Me I Matter
“Are not five sparrows sold for two pennies? Yet not one of them is forgotten by God.” – Luke 12:6
Father, remind me that my life matters. Speak truth over the lies in my mind. Amen.
12. Carry Me Through
“Even to your old age… I am he who will sustain you and carry you.” – Isaiah 46:4
God, I don’t have the strength to move forward today. Please carry me. Amen.
13. Speak to My Soul
“Why, my soul, are you downcast? Put your hope in God.” – Psalm 42:11
Lord, speak hope to my soul. Tell me again that it will get better. Amen.
14. Calm the Noise
“In quietness and trust is your strength.” – Isaiah 30:15
Jesus, quiet my racing thoughts. Let Your stillness surround me. Amen.
SEE ALSO: 40 Short Prayer to Comfort a Grieving Friend
15. Just Show Up
“Call to me and I will answer you.” – Jeremiah 33:3
Lord, I don’t even know what to pray. Just show up in my mess. Amen.
16. Give Me Rest
“He makes me lie down in green pastures, he leads me beside quiet waters.” – Psalm 23:2
Father, lead me to rest. Let me lay down my burdens, even if only for a moment. Amen.
17. A New Day
“Because of the Lord’s great love we are not consumed… His mercies are new every morning.” – Lamentations 3:22-23
God, thank You for this new day. Help me find Your mercy in it. Amen.
18. When I’m Afraid
“When I am afraid, I put my trust in you.” – Psalm 56:3
Lord, fear is loud. Let my trust in You be louder. Amen.
19. Rescue My Mind
“Take captive every thought to make it obedient to Christ.” – 2 Corinthians 10:5
Jesus, take my thoughts. Rescue me from despair. Amen.
20. You Are My Safe Place
“You are my hiding place; you will protect me from trouble.” – Psalm 32:7
God, let me hide in You. Keep me safe from the storms in my mind. Amen.
21. I Am Still Yours
“Fear not, for I have redeemed you; I have called you by name, you are mine.” – Isaiah 43:1
Lord, even in my depression, remind me—I still belong to You. Amen.
22. When I Feel Worthless
“You are precious and honored in my sight.” – Isaiah 43:4
God, tell me again that I’m precious to You. Let me believe it. Amen.
23. Hold Me Together
“He is before all things, and in him all things hold together.” – Colossians 1:17
Jesus, hold my life together when I feel like falling apart. Amen.
24. Replace the Lies
“Then you will know the truth, and the truth will set you free.” – John 8:32
God, replace the lies in my mind with Your truth. Set me free. Amen.
25. Faith in the Fog
“Now faith is confidence in what we hope for.” – Hebrews 11:1
Lord, help me believe even when I can’t see the way forward. Amen.
26. Still Chosen
“You did not choose me, but I chose you.” – John 15:16
God, thank You for choosing me—depression and all. Amen.
27. Anchor My Heart
“We have this hope as an anchor for the soul, firm and secure.” – Hebrews 6:19
Anchor my heart in Your love, Lord. Keep me from drifting too far. Amen.
28. You’re Still in Control
“The Lord has established his throne in heaven, and his kingdom rules over all.” – Psalm 103:19
Even in my mess, You reign. Rule over my brokenness too, Lord. Amen.
29. Lighten the Load
“Cast all your anxiety on him because he cares for you.” – 1 Peter 5:7
Jesus, I give You this weight. Please lighten my soul. Amen.
30. A Breakthrough is Coming
“Weeping may stay for the night, but rejoicing comes in the morning.” – Psalm 30:5
Lord, bring the morning. Let joy come again. Amen.
31. You Know My Pain
“Surely he took up our pain and bore our suffering.” – Isaiah 53:4
Jesus, You understand my pain. Walk through it with me. Amen.
32. Let Me Feel Again
“I will remove from you your heart of stone and give you a heart of flesh.” – Ezekiel 36:26
God, let me feel again. Let joy and hope come back. Amen.
33. I Can Still Trust You
“Trust in the Lord with all your heart.” – Proverbs 3:5
Lord, I may not understand, but I still choose to trust You. Amen.
34. Break the Chains
“He brought them out of darkness… and broke away their chains.” – Psalm 107:14
Break the chains of depression, Lord. Set me free. Amen.
35. Show Me Purpose
“For we are God’s handiwork, created in Christ Jesus to do good works.” – Ephesians 2:10
God, remind me why I’m here. Show me there’s still purpose. Amen.
36. You Never Change
“Jesus Christ is the same yesterday and today and forever.” – Hebrews 13:8
When everything shifts, be my steady place, Lord. Amen.
37. Guard My Heart
“And the peace of God… will guard your hearts and your minds.” – Philippians 4:7
God, guard me from despair. Keep my heart safe in You. Amen.
38. Help Me Forgive Myself
“There is now no condemnation for those who are in Christ Jesus.” – Romans 8:1
Lord, help me let go of guilt and forgive myself. Amen.
39. I’m Still Breathing
“Let everything that has breath praise the Lord.” – Psalm 150:6
As long as I have breath, I will keep turning to You, God. Amen.
40. Let Me Rise Again
“Though I fall, I will rise. Though I sit in darkness, the Lord will be my light.” – Micah 7:8
Lord, lift me up again. Let me rise from this place. Amen.
Depression can make us believe we are forgotten, unloved, or beyond repair. But God sees through the fog. He remembers every tear and hears every silent cry. These 40 powerful prayer for depression are a lifeline—not because the words are perfect, but because God is. Each prayer is a reminder that even in your lowest valley, the Shepherd walks with you.
Let these 40 powerful prayer for depression become part of your daily rhythm. Read them aloud. Whisper them at night. Return to them when your heart feels heavy. These prayers are steps toward healing, one moment at a time.
You are not alone. You are not abandoned. The God who made you still holds you, still loves you, and still has a plan for you.
Say these 40 powerful prayer for depression again and again. Let them lift your spirit, restore your faith, and breathe new strength into your journey. Your story is not over—and joy will return.
